Alexander L. Sukstanskii1, James D. Quirk1, Jason C. Woods1,2, David S. Gierada1, Barbara A. Lutey3, Mark S. Conradi2, Dmitriy A. Yablonskiy1,2
1Radiology, Washington University, St. Louis, Misssouri, United States; 2Physics, Washington University, St. Louis, MO, United States; 3Internal Medicine, Washington University, St. Louis, MO, United States
The apparent diffusion coefficient (ADC) of hyperpolarized 3He gas in lungs increases in emphysema and can serve as a biomarker of the disease progression. It is not clear, however, how ADC relates to lung microstructure. In the present communication, using 3He-based in vivo lung morphometry technique, we demonstrate that ADC and a standard histological parameter mean chord length (Lm) reflect lung microstructure parameters in different ways. As a result, a there is no unique relationship between ADC and Lm. At the same time, 3He-based lung morphometry allows quantification of the lung microstructure in terms of Lm, surface-to-volume ratio and other standard histological parameters.