Nicholas James Tustison1, Talissa A. Altes2,
G. Wilson Miller2, Eduard E. de Lange2, John P. Mugler
III2, James C. Gee1
1Radiology, University of Pennsylvania,
Philadelphia, PA, United States; 2Radiology, University of
Virginia, Charlottesville, VA, United States
We
present an open source bias correction algorithm based on the popular N3
algorithm and demonstrate its superior performance for nonuniform intensity
correction in hyperpolarized helium-3 lung images.