Meng Yin1, Kevin J. Glaser1, Jun Chen1, Jayant A. Talwalkar2, Armando Manduca1, Richard L. Ehman1
1Department of Radiology, Mayo Clinic,
One advantage of liver MR elastography (MRE) over biopsy or ultrasound-based transient elastography is its ability to reduce sampling errors by measuring liver stiffness over a large portion of the liver. While existing 2-D or localized approaches yield valid results in a substantial part of the volume, a full 3-D/3-axis wave analysis is required for valid measurements of stiffness throughout the entire liver. This investigation compares a 2-D and a 3-D approach for liver MRE and demonstrates that 3-D MRE analysis improves the homogeneity of hepatic stiffness estimates.