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Abstract #2605

Fast 3D Dynamic Contrast-Enhanced MRI Pre- And Post-Secretin for Evaluating the Severity of Chronic Pancreatitis

Patrick Hawkins1, Numan C. Balci2, Sharon C. Forrest3, Frank Burton4, Samer Alkaade4, Thomas Perkins5, William H. Perman1

1Radiology, Saint Louis University School of Medicine, St. Louis, MO, United States; 2Radiology, Saint Louis University, St. Louis, MO, United States; 3Department of Radiology, Saint Louis University Hospital, St. Louis, MO, United States; 4Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, United States; 5Philips Healthcare, Cleveland, OH, United States


Currently, secretin stimulation is utilized in MRCP Cambridge classification of chronic pancreatitis. Our study intends to correlate pre- and post-secretin pancreas perfusion with a more precise classification of chronic pancreatitis. Fast 3D dynamic contrast-enhanced MR perfusion scans were performed on 12 subjects with suspected chronic pancreatitis using a 3D T1 weighted turbo field echo pulse sequence. Comparison of the perfusion values between Cambridge type 3 and type 1 subjects, with normal exocrine function demonstrate a significant difference in regional and average arterial to tissue wash-in and wash-out rates. Conclusion: Contrast-enhanced MRI shows promise as a staging technique for chronic pancreatitis.