Dania Daye1, Kejia Cai2, Mohammad Haris2, Anup Singh2, Santosh Gaddam2, Rebecca Wells3,4, Emma Furth, Ravinder Reddy2
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Medicine, University of Pennsylvania, Philadelphia, PA; 4Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
It has been previously shown that T1ρ weighted MR imaging has significant potential to provide for a non-invasive assessment of liver disease, specifically in fibrosis. In T1ρ weighted imaging, nuclear spins are locked with a radiofrequency locking field, yielding a longitudinal relaxation time (T1ρ) in the rotating frame. By varying the strength of the locking field (B1), it is possible to make the T1ρ relaxation time changes sensitive to different contrast mechanisms in tissues. Here, we show that that T1 ρ dispersion technique has significant potential to differentiate between different liver pathologies as well al further characterize certain pathologies, such as fibrosis.