Jingjing Xu1, Changqin Liu2,
Shuhui Cai1, Jiyang Dong1, Zhong Chen1
1Department of Physics, Fujian Key
Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen,
Fujian, China; 2The First Hospital of Xiamen Affiliated to the
Xiamen University, China
The
biochemical variations of urine from chow- and high fat-fed rats were
investigated using NMR-based metabolomics. Two groups can be discriminated
clearly according to the scores plot of partial least squares discriminant
analysis. The plot of variable importance in projection shows that taurine,
succinate, hippurate, choline, citrate, dimethylamine, acetate,
dimethylglycine, creatine, creatinine, tyrosine, glycine and lactate are
contributed to the classification. In addition, the metabolic change with the
development of obesity was also explored.