Kenneth
Hollander1, Catherine Tempel-Brami2, Fred M. Konikoff1,
Menahem Fainaru3, Alicia Leikin-Frenkel1
1Minerva Center for Lipid Metabolism in
the Liver, Sackler School of Medicine, Tel Aviv University, Israel; 2Alfredo
Federico Strauss Center for Computational Neuro-Imaging, Tel Aviv University,
Tel Aviv, Israel; 3Department of Physiology, Sackler School of
Medicine, Tel Aviv University, Tel Aviv, Israel
The
mammalian fetus is completely dependent on the fatty acids supplied by its
mother inside the uterus. In the present study we analyzed the impact of
fatty acids in pregnant mother's isocaloric diet on obesity and insulin
resistance in adult offspring (DOAD). Body fat in pregnant mothers and
offspring was measured by MRI and correlated with tissues fat and insulin
resistance in adult offspring. Essential Fatty Acids prevented adult
offspring obesity and insulin resistance whereas saturated fatty acids
promoted it. MRI measured body fat correlated with HOMA index, tissues lipid
content and SCD activity in white adipose tissue.