MingMing Li1, Beau Pontre2, Stephen Pickup3, Hong Xu4, Anthony Philips2, Garth Cooper2, Jun Lu2,5
1School of Biological Sciences, Auckland University, Auckland, New Zealand; 2School of Biological Sciences, Auckland University, New Zealand; 3Department of Radiology, University of Pennsylvania, Philadelphia, United States; 4College of Chemistry and Chemical Engineering, Shen Zhen University, Shenzhen, Guangdong, China; 5NCIECP, Auckland University of Technology, Auckland, New Zealand
We hypothesise that chemically induced Spermidine/spermine acetyl transferase (SSAT) activity, which stimulates polyamine catabolism and in turn enhances fat/glucose metabolism, would decrease fat content and improve cardiac function in obese mice. C57Bl/6 and matched leptin deficiency (ob/ob) mice were treated with a potent SSAT inducer, N1, N11-diethylnorspermine (DENS), through i.p. injection. Results showed that DNES not only can significantly reduce body fat percentages in both mice models, but also can control ob/obs body weight. Moreover, DENS can prevent the development of cardiac hypertrophy in obese mice. Therefore, SSAT is a potential target for the development of pharmacotherapy in obesity.