Abstract #2688

Comparison of DCE-MRI and DCE-CT in Patients with Renal Cell Carcinoma: Effects of Temporal Resolution and Total Measurement Time

Colleen Bailey^1,2, Mostafa Atri³, Georg A. Bjarnason¹, Greg J. Stanisz^1,2

¹Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ²University of Toronto, Toronto, ON, Canada; ³University Health Network, Toronto, ON, Canada

Patients with renal cell carcinoma were scanned with DCE-MRI (temporal resolution 3.7 s) and DCE-CT (temporal resolution 1 s). ROIs across the tumour volume were analyzed using the Kety-Tofts two-compartment model of perfusion. The volume transfer constant, K_trans, did not correlate between the two modalities. The extravascular extracellular volume, v_e, showed weak correlation. Undersampling the DCE-CT data to similar temporal resolution as the DCE-MRI data systematically underestimated K_trans, whereas restricting the DCE-MRI data, initially acquired over five minutes, to the two minute acquisition time of the DCE-CT data resulted in a systematic underestimation of v_e and an overestimation of K_trans.