Colleen Bailey1,2, Mostafa Atri3, Georg A. Bjarnason1, Greg J. Stanisz1,2
1Sunnybrook Health Sciences Centre,
Patients with renal cell carcinoma were scanned with DCE-MRI (temporal resolution 3.7 s) and DCE-CT (temporal resolution 1 s). ROIs across the tumour volume were analyzed using the Kety-Tofts two-compartment model of perfusion. The volume transfer constant, Ktrans, did not correlate between the two modalities. The extravascular extracellular volume, ve, showed weak correlation. Undersampling the DCE-CT data to similar temporal resolution as the DCE-MRI data systematically underestimated Ktrans, whereas restricting the DCE-MRI data, initially acquired over five minutes, to the two minute acquisition time of the DCE-CT data resulted in a systematic underestimation of ve and an overestimation of Ktrans.