Meeting Banner
Abstract #2705

Theranostic Effect of Serial MEMRI on the HESC Induced Teratoma

Jaehoon Chung1, Rajesh Dash1, Kehkooi Kee2, Joelle Barral3, Irving Weissmann4, Dwight Nishimura3, Robert Robbins5, Renee Reijo Pera2, Phillip C. Yang1

1Cardiovascular medicine, Stanford University, Stanford, CA, United States; 2Stem cell biology and regenerative medicine, Stanford University, Stanford, CA, United States; 3Electrical engineering, Stanford University, Stanford, CA, United States; 4Pathology, Stanford University, Stanford, CA, United States; 5Cardiothoracic surgery, Stanford University, Stanford, CA, United States


Systemic administration of MnCl2 enabled simultaneous monitoring and selective elimination of hESC induced teratoma cells by higher intracellular accumulation of Mn2+. This is the first study to demonstrate MEMRI has a theranostic effect in both detecting and eliminating early teratoma formation.