Andreas
Steingoetter1,2, Jonas Svensson3, Yvonne Kosanke1,
Ernst Rummeny1, Rickmer Braren1
1Institute of Radiology, Klinikum
rechts der Isar der TU Mnchen, Munich, Germany; 2Institute for
Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 3Department
of Medical Radiation Physics, Malmo University Hospital, Lund University,
Malmo, Sweden
A
limitation in DCE-MRI is the difficulty of simultaneous measurement of
arterial input function and CA concentration in tumor tissue. In this study,
two anaesthesia protocols, resulting in a ~ 30% change in heart rate, were
used to simulate systemic changes in AIF to analyze the robustness of popAIF
vs RR modeling in an orthotopic HCC rat tumor model. Different anaethesisa
protocols resulted in a significant systematic offset for popAIF based ktrans
and ve modeling compared to RR. This study highlights the robustness and
feasibility of the reference region approach.