Dustin K. Ragan1, Stephen Yenzen Lai2, James A. Bankson1
1Department of Imaging Physics, M. D. Anderson Cancer Center, Houston, TX, United States; 2Department of Head and Neck Surgery, M. D. Anderson Cancer Center, Houston, TX, United States
Measurement of pharmacokinetic parameters in small animal models of cancer is a frequently-used tool in preclinical investigations of novel interventions. One source of uncertainty from these measurements arises from the challenges of quantifying the concentration time course of a contrast agent in blood. We have proposed performing this measurement in the heart, which allows reduced-artifact high temporal resolution sampling. A pilot study was performed in a thyroid tumor model comparing the inter-subject variation produced by cardiac sampling with conventional sampling in a local blood vessel, and found a large reduction in variation with the proposed approach.