Septian Hartono1,2, Choon Hua Thng1, Tong San Koh2, Puor Sherng Lee1, Fang Keang Lim1, Theng Boon Lee1, Helmut Rumpel3, Quan Sing Ng1
1National Cancer Centre
Hollow Fiber Bioreactors (HFBs), typically used for cell culture, mimicks well the human capillary system and thus is ideal to be used to validate the microcirculatory parameters obtained by tracer kinetic modeling. The aim of this study is to validate the permeability-surface area product (PS) obtained by tracer kinetic models with DCE-MRI in a HFB. Linear relationship was found between PS derived from the tracer kinetic models and pore size area of the HFBs.