Tone Frost Bathen1, Beathe Sitter1,
Guro F. Giskedegrd1, Lutgarde Buydens2, Geert Postma2,
Hans Fjsne3, Steinar Lundgren1,4, Ingrid S. Gribbestad1
1Dept. of Circulation and Medical
Imaging, NTNU, Trondheim, Norway; 2Dept. of Analytical Chemistry,
Radboud University Nijmegen, Nijmegen, Netherlands; 3Dept. of
Surgery, St. Olavs University Hospital, Trondheim, Norway; 4Dept.
of Oncology, St.Olavs University Hospital, Trondheim, Norway
The
purpose of the current study was to define new prognostic factors for breast
cancer based on HR MAS MRS. Proton MR spin echo spectra were acquired from
excised breast cancer tissue. 5-years follow-up data were available for all
included patients. The spectra were analysed with PCA. Using ROC and
Kaplan-Meyer survival analysis of score values, two groups with significant
different cumulative survival were defined. Higher levels of
glycerophosphocholine, betaine and creatine, and lower levels of lactate and
glycine were associated to good prognosis. A combination of MR determined
metabolites may serve as an additional prognostic factor in breast cancer.