Abstract #2773

Hyperpolarized 13C Biomarkers of Androgen Independent Prostate Cancer

Paniz Vafaei¹, Robert Bok¹, Lynn DeLosSantos, Vicki Zhang, Phillip Guan, Dan Vigneron, John Kurhanewicz

¹Radiology, University of California, San Francisco, San Francisco, CA, United States

Androgen independence of prostate cancer is an important clinical status to identify, but no well-defined biomarkers for this state exist. In this study we used fast 13C-MRSI after injection of hyperpolarized [1-13C] pyruvate and pathological and biochemical analysis of the tumor to determine hyperpolarized (HP) biomarkers of androgen dependent and androgen independent prostate cancer. Androgen independent phenotype had a significantly higher HP lactate/noise, Total Hyperpolarized Carbon, HP lactate/pyruvate, and LDH activity relative to the androgen dependent phenotype.