Lilia V. Ileva1, Marcelino Bernardo2,3, Diane Palmieri4, Patricia Steeg4, Joseph Kalen1, Peter Choyke2
1Small Animal Imaging Program, SAIC-Frederick, NCI-Frederick, Frederick, MD, United States; 2Molecular Imaging Program, NCI, NIH, Bethesda, MD, United States; 3Imaging Physics, SAIC-Frederick, NCI-Frederick, Frederick, MD, United States; 4Laboratory of Molecular Pharmacology, NCI, NIH, Bethesda, MD, United States
Multiple mouse MRI is of critical importance in preclinical cancer research when longitudinal studies with multiple animals is required. This work presents a four-mouse brain imaging coil system and its application in the development of a breast cancer brain metastasis mouse model. The four-mouse SENSE array is integrated in a single platform with physiological support system. Six imaging sessions on 18 mice were performed weekly to monitor the initiation and progression of the brain metastases. The usage of the multiple mouse brain coil system significantly improved the efficiency of MRI studies involving serial imaging of multiple small animals.