1Radiation Medicine Program, Princess
Margaret Hospital, Toronto, Ontario, Canada; 2Medical Imaging,
University Health Network, Toronto, Ontario, Canada; 3Medical
Imaging, University of Toronto; 4Sunnybrook Research Institute,
Toronto, Ontario, Canada
A
magnetization-prepared spiral imaging strategy with RF cycling has been
adapted for time-efficient multi-slice clinical prostate T1 quantification at
1.5T. In vitro testing validated an
overall robustness to RF offsets.
Pilot studies in patients without prior external beam radiation
demonstrated an equivalence between zonal T1, with reduced T1 in peripheral
zone tumors. Intra-patient zonal T1
variabilities motivate individial measurements for dynamic studies of
vascular metrics. SNR analysis
identified useful region volumes for thermal-noise insensitive measurements,
to guide protocol design for future voxel-based prostate T1 mapping. High RF insensitivity combined with
time-efficiency suggests method potential for robust implementation on
stronger magnets.