Piotr Kozlowski1,2, Silvia D. Chang2, Edward C. Jones3, Ran Meng1, Nicholas Buchan4, S Larry Goldenberg, 4,5
1UBC MRI Research Centre, Vancouver, BC, Canada; 2Radiology, Univeristy of British Columbia, Vancouver, BC, Canada; 3Pathology and Laboratory Medicine, Univeristy of British Columbia, Vancouver, BC, Canada; 4Vancouver Prostate Centre, Vancouver, BC, Canada; 5Urologic Sciences, Univeristy of British Columbia, Vancouver, BC, Canada
DTI and DCE MRI were carried out in 27 prostate cancer patients. Mean diffusivity, fractional anisotropy and pharmacokinetic modeling parameters calculated from MRI data were correlated with Gleason score determined by biopsy and prostatectomy specimens. Mean diffusivity and fractional anisotropy correlated significantly with Gleason score, as demonstrated by the Spearmans rank correlation test and the ordinal logistic regression modelling. These results strongly suggest that DTI MRI is capable of non-invasively grading prostate tumours.