Jacobus FA Jansen1, Diane Carlson1, Bhuvanesh Singh1, Hilda Stambuk1, Ya Wang1, Dennis Kraus1, Richard Wong1, Snehal Patel1, Jatin Shah1, Jason Koutcher1, Amita Shukla-Dave1
Pretreatment DCE-MRI was performed on neck nodal metastases of 12 patients who underwent surgery. Surgical specimens were analyzed with immunohistochemistry (IHC) assays for Ki-67 (reflecting cellular proliferation) and HIF-1α (hypoxia inducible transcription factor). Spearman correlation was used to correlate DCE-MRI and molecular marker data. Significant correlation results were observed between DCE-MRI data (Ktrans and ve) and tumor hypoxia, and proliferation as measured by Ki67 and HIF-1 expression levels, respectively. Future studies with larger patient populations need to be carried out to confirm pretreatment DCE-MRI findings and molecular marker results in biopsy samples for better patient management.