Astrid L.H.M.W. van Lier1, Alexander J. Raaijmakers1, David O. Brunner2, Dennis W.J. Klomp3, K. P. Pruessmann2, Jan J.W. Lagendijk1, Cornelis A.T. van den Berg1
1Radiotherapy, UMC Utrecht, Utrecht, Netherlands; 2Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland; 3Radiology, UMC Utrecht, Utrecht, Netherlands
From basic EM (electromagnetic) theory we know that the wavelength, thus the propagating phase, depends on the permitivity and conductivity. Analysis, based on simulations, showed that local changes in the conductivity, have the largest effect on the propagating phase in the physiological range. We demonstrated that it is possible to measure the effect both in phantoms and in vivo, with results comparable to results of EM simulations. This new contrast mechanism might be useful for the detection of conducting malignancies, such as breast tumours.