Colin Morehouse Carpenter1, Shudong Jiang2, Brian William Pogue2, Keith David Paulsen2
1Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States; 2Thayer School of Engineering at Dartmouth, Hanover, NH, United States
IDEAL water/fat separation was used to improve hemoglobin quantification of MR-guided optical imaging. This technique is shown to reduce the cross-talk between oxyhemoglobin and water, caused by the spectral similarity of these tissue constituents in the near-infrared. It is demonstrated in gelatin phantoms that this approach reduces error in oxyhemoglobin by 70% on average for several cases. This finding has significant benefit for optical breast imaging, as the improved quantification provided by the MR water image can be leveraged to reduce the number of wavelengths in the optical data acquisition and thus increase temporal resolution.