Miriam
Rabea Kubach1, Kaveh Vahedipour2, Ana Maria
Oros-Peusquens2, Tony Stoecker2, N. Jon Shah2,3
1Institute of Neuroscience and Medicine
, Forschungszentrum Juelich, Juelich, Germany; 2Institute of
Neuroscience and Medicine, Forschungszentrum Juelich, Juelich, Germany; 3Faculty
of Medicine, Department of Neurology, , RWTH Aachen University, JARA,, Aachen, Germany
T1
is an MRI parameter very sensitive to pathological changes. Proper T1-mapping
is therefore vital for many MRI applications, but the variability of T1
values within different methods is larger than within a group of volunteers
measured with the same method. The accuracy of the T1 determination is
affected by a number of rectifiable parameters but also influenced by MT in
ways, which are strongly method-dependent and usually not quantified. We
present numerical simulations, based on an existing software package JEMRIS,
which allow one to simulate MR sequences considering MT effects. We
investigate changes in the T1 relaxation of the observable water component
due to the presence of and exchange with a bound proton pool. A simple
pulse-acquire sequence is used for simulations, which can be the elementary
building block of more realistic MR imaging sequences.