Matthew T. Latourette1, James E. Siebert1
In longitudinal research studies that employ R2*/T2* quantitation, reference phantoms can serve to improve the sensitivity and reproducibility of R2* measurements through detection and correction of bias and reduction of the variance of pooled study data. Stable phantoms comprised of agarose and carageenan gel doped with SPIO, NiCl2, and methylisothiazolinone were developed, enabling reliable R2* measurements that are adequately insensitive to temperature variations near room temperature. The phantoms R2* dependence on B0 was evaluated at field strengths of 0.35T, 0.7T, 1.5T, 3.0T. Chemical stability has been evaluated since phantom construction in April 2009.