Rebecca Sara Samson1, Matthew Clemence2, Xavier G. Golay3, Claudia A M Wheeler-Kingshott1
1NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Philips Clinical Science Group, Philips Healthcare, Guildford, United Kingdom; 3NMR Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
RF B1 transmit field non-uniformity, caused primarily by skin depth and dielectric resonance effects, is a large source of error in quantitative MR measurements made at 3.0T. We investigated the possibility that B1 errors could be reduced using dual transmission by measuring the MTR and B1 with and without dual transmission. We present preliminary data acquired on three healthy subjects indicating that it may be possible to reduce inter-subject variation in MTR histogram peak locations via the use of dual transmission at 3.0T. This could be an important consideration when designing future long-term clinical studies using quantitative MRI outcome measures.