Timo Liimatainen1, Olli Grhn2
1Department of Biotechnology and Molecular Medicine, University of Kuopio, Kuopio, Finland; 2Department of Neurobiology, University of Kuopio, Kuopio, Finland
A pulse sequence based on gradient echo design was modified to include four hyperbolic secant pulses, following by a signal acquisition. This was repeated four times to obtain a T1ρ weighted signal intensity curve with incrementally increasing spin-lock time for single phase encoding step. T1ρ relaxation times were compared between developed method and spin echo readout with a T1ρ preparation pulse train in mice brains. Similar T1ρ values were obtained with both methods. The developed method allows acquisition of several incremented spin-lock times within one repetition time enabling faster quantization of T1ρ and/or decreased specific absorption rates.