Hye Young Heo1, Nader Dahdaleh1, Daniel Thedens1, Bradley Bolster2, John Wemmie1, Vincent Magnotta1
The purpose of this study is to determine the ability of magnetic resonance (MR) imaging to assess regional pH levels. Both phantom and mouse models were used to evaluate pH sensitive changes in T1ρ imaging. A linear relationship was observed between T1ρ time and pH. In the mouse model, widespread increases in T1ρ times during CO2 inhalation were found consistent with the expected acidosis, whereas reduced T1ρ times during HCO3- injection were found to be consistent with the expected alkalosis.