Se Young Chun1, Sanghee Cho1, Tim
G. Reese2, Bastien Guerin1, Xuping Zhu1,
Jinsong Ouyang1, Ciprian Catana2, Georges El Fakhri1
1Division of Nuclear Medicine &
Molecular Imaging, Department of Radiology, Massachusetts General Hospital,
Boston, MA, United States; 2Athinoula A. Martinos Center for
Biomedical Imaging, Department of Radiology, Massachusetts General Hospital,
Boston, MA, United States
This
abstract reports preliminary results of motion corrected MR-PET reconstruction
based on B-spline nonrigid image registration and compares it with HARP based
motion compensation. With a breathing phantom, we collected MR and PET data
simultaneously using BrainPET prototype PET scanner operating in the bore of
a 3T TIM Trio scanner. Then we estimate the motion of a phantom using HARP
and proposed B-spline based image registration with a novel invertibility
penalty. These estimated motions were used in motion compensated iterative
PET reconstruction. This preliminary result shows significant improvement of
PET images for large motions.