Francesca C. Norris1,2, Jon O. Cleary1,3, Marc Modat4, Anthony N. Price1, Karen McCue5, Sarah Beddow5, Peter J. Scambler5, Sebastien Ourselin4, Mark F. Lythgoe1
1Centre for Advanced Biomedical Imaging, Department of Medicine and UCL Institute of Child Health, University College London, London, United Kingdom; 2Centre for Mathematics and Physics in the Life Sciences and EXperimental Biology (CoMPLEX), University College London, London, United Kingdom; 3Department of Medical Physics and Bioengineering, University College London, London, England, United Kingdom; 4Centre for Medical Image Computing, University College London, London, United Kingdom; 5Molecular Medicine Unit, UCL Institute of Child Health, University College London, London, United Kingdom
The increasing use of genetically modified mice has highlighted the need for effective phenotyping methods. Propagation-based morphometry (PBM) is an emerging technique enabling non-invasive and rapid acquisition of volumetric data using an average population atlas for morphometric analysis. Thus, PBM shows promise for combining high-throughput MR imaging of late-gestation embryos with high-throughput analysis. We present the first study to assess and validate the accuracy of volumes generated via PBM in an ex vivo mouse embryo atlas comprising three different groups. Preliminary results show promise towards the broad applicability of this technique for phenotyping mutant mouse models.