Jelle
Veraart1, Bjornar T. Antonsen2, Ines Blockx3,
Wim Van Hecke4,5, Yi Jiang6, G. Allen Johnson6,
Annemie Van Der Linden3, Trygve B. Leergaard2, Marleen
Verhoye3, Jan Sijbers1
1Vision Lab, University of Antwerp,
Antwerp, Belgium; 2Center for Molecular Biology and Neuroscience,
Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; 3Bio
Imaging Lab, University of Antwerp, Antwerp, Belgium; 4Department
of Radiology, University Hospital Antwerp, Antwerp, Belgium; 5Department
of Radiology, University Hospitals of the Catholic University of Leuven,
Leuven, Belgium; 6Duke Center for In Vivo Microscopy, Duke
University Medical Center, Durham, NC, United States
An
anatomically labeled DTI atlas of the adult Sprague Dawley brain is proposed.
The atlas is constructed using a population based atlas construction approach
to create a template which represents the average anatomy. Further, a bias to
a single subject is minimized. During the construction, a non-rigid
coregistration technique is used to avoid local misalignment inaccuracies due
to intersubject differences. The
delineation of brain structures was performed on high resolution ex-vivo
scans and the resulting parcellation maps were non-linearly warped into the
in-vivo atlas space afterwards. The atlas is perfectly suited for automated
ROI analysis and more standardized VBA studies.