Silvia De Santis1,2, Silvia Capuani1,2, Andrea Gabrielli3,4, Bruno Maraviglia, 1,5
1Physics department, Sapienza University, Rome, Italy; 2INFM-CNR SOFT, Sapienza University, Rome, Italy; 3SMC - CNR/INFM, Sapienza University, Rome, Italy; 4ISC - CNR, Rome, Italy; 5Neuroimaging Laboratory, S. Lucia Foundation, Rome, Italy
We propose a new procedure to detect the deviation from the mono-exponentiality of water diffusion in brain. The stretched-exponential model has been extended to three-dimensional space to obtain new scalar invariants. The potentiality of this methodology has been evaluated on young healthy subjects. Statistical analysis on selected ROIs from different cerebral tissues underlined a different contrast compared to conventional DTI one. In particular, GM and WM can be discriminated on the basis of their microstructural complexity, underlying a chance for investigating subtle changes of the water diffusive motion in tissues which are not detected by conventional MD and FA indexes.