Kelsey Mairead Mountain1,2, Tadeusz Foniok3,
Jeff Dunn, 1,3, John Robert Matyas, 2,4
1Biomedical Engineering, University of
Calgary, Calgary, Alberta, Canada; 2McCaig Institute for Bone and
Joint Health, Calgary, Alberta, Canada; 3National Research Council
Canada, Calgary, Alberta, Canada; 4Faculty of Veterinary Medicine,
University of Calgary, Calgary, Alberta, Canada
The
superficial zone of articular cartilage is a dense network of ordered
collagen fibres running parallel to the articular surface. The initial
histopathological changes of osteoarthritis (OA) occur at this surface; and
if detected, could provide insight into OA progression. High-field MRI can
detect collagen organization based on changes in T2 relaxation. In this
study, T2 was used to assess articular cartilage surface collagen in an
animal model of osteoarthritis.