Jos G. Raya1,
Annie Horng2, Lorenz Knig3, Maximilian F. Reiser2,
Christian Glaser2
1Josef Lissner Laboratory for Biomedial
Imaging, , University of Munich, Munich, Germany; 2Department of
Clinical Radiology, University of Munich; 3Technical University of
Munich
MRI-based
quantification of the cartilage thickness is a robust and well validated
technique for the assessment of cartilage degradation in osteoarthritis, and
for the analysis of cartilage deformations after exercise. Nowadays changes
in cartilage thickness are evaluated by comparing averaged thickness over
regions defined on an anatomical basis. In this work we demonstrate that
working with a sub-voxel precision allow detecting statistically significant
changes in the cartilage thickness between longitudinally acquired datasets
with sub-voxel precision. The method has been tested on a small group of
healthy volunteers by measuring them before and after 20 min squatting.