Gregory Chang1, Klaus M. Friedrich2, Ligong Wang3, Graham C. Wiggins3, Michael Recht, Guoyuan Liang4, Punam K. Saha5, Ravinder R. Regatte3
1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Radiology, Medical University of Vienna, Austria; 3Radiology, NYU Langone Medical Center, New York, United States; 4Electrical and Computer Engineering, Iowa City, IA, United States; 5Radiology and Electrical & Computer Engineering, Iowa City, IA, United States
In this study, we performed a regional and subregional quantitative assessment of trabecular bone micro-architecture of the knee in subjects with osteoarthritis (OA) using high spatial resolution MRI at 7 Tesla. OA subjects demonstrated decreases in numerous parameters of trabecular bone morphology and topology compared to healthy controls. Subregional analyses within the medial femoral condyle, lateral femoral condyle, medial tibial plateau, and lateral tibial plateau allowed the detection of smaller geographic areas of abnormal trabecular bone micro-architecture in OA subjects. This technique may allow more accurate characterization of the spatial distribution of the pathologic changes in the osteoarthritic knee.