Ihssan S. Masad1,2, Y-M Park3,
S-R Lee3, Jacob M. Wilson3, Paul C. Henning3,
Bahram H. Arjmandi3, Samuel Colles Grant1,2, J-S Kim3
1Department of Chemical &
Biomedical Engineering, The Florida State University, Tallahassee, FL, United
States; 2National High Magnetic field Laboratory, Tallahassee, FL,
United States; 3Department of Nutrition, Food & Exercise
Sciences, The Florida State University, Tallahassee, FL, United States
SSarcopenia,
age-related muscle wasting, has drastic medical and financial impacts on the
elderly population. In this study, diffusion tensor imaging (DTI), which is
sensitive to muscle architecture, is employed to assess the potential
benefits of β-hydroxy-β-methylbutyrate (HMB) and resistance
training (RT) in a pre-clinical model of aged rats. DTI was used to evaluate
muscle cross sectional area (CSA) while dual energy X-ray absorptiometry was
utilized to assess lean body mass (LBM). As well as increasing LBM, results
demonstrate that RT caused hypertrophy in aged soleus muscle, as indicated by
increased ADC as well as increased second and third eigenvalues.