Ashok Sharma1, Uma Sharma2, N R. Jagannathan2, Moganty R. Rajeswari1
1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India
MR relaxometry offers the potential for investigating the microstructural tissue properties and the ability to detect early changes of water mobility resulting from therapy-induced changes. In this study we report the cisplatin induced cell death with the duration of treatment by MR relaxometry in an animal model of squamous cell carcinoma of skin. Our MR data correlated with the findings of histology and biochemical parameters i.e proliferation index and apoptotic index. Results indicate that MR relaxometry measurements are useful to monitor cell death in response that could help selection of proper therapeutic regimen, dose, or duration of drug.