Matthew E. Merritt1,2,
1Advance Imaging Research Center, UT
Southwestern Med. Center, Dallas, TX, United States; 2Radiology,
UTSW Medical Center, Dallas, TX, United States; 3Physics,
University of Texas at Dallas, Richardson, TX, United States; 4AIRC,
UTSW Medical Center, Dallas, TX, United States; 5Chemistry,
University of Texas at Dallas, Richardson, TX, United States; 6Cardiology,
North Texas VA Hospital, Dallas, TX, United States; 7Radiology,
Washington University in St. Louis, St. Louis, MO, United Kingdom
A
primary challenge to extracting quantitative metabolic fluxes from metabolism
of a hyperpolarized substrate is modeling the delivery of the molecular imaging
agent itself. Here, a tracer is co-infused with [1-13C] pyruvate.
A model of the delivery and decay of the magnetization is analyzed with a
Bayesian approach, yielding a delivery rate with the standard deviation. Such
models are a necessary precursor to correct modeling of fluxes in vivo.