Florian Wiesinger1, Marion I. Menzel1, Eliane Weidl2, Martin Janich1,3, Markus Schwaiger2, Rolf F. Schulte1
1Imaging Technologies, GE Global Research, Munich, Germany; 2Institute for Nuclear Medicine, Technical University Munich, Munich, Germany; 3Department of Chemistry, Technical University Munich, Munich, Germany
Hyperpolarized [1-13C]pyruvate has demonstrated significant potential for metabolic MR imaging. In-vivo metabolism converts pyruvate into a limited number of 13C detectable downstream metabolites (including lactate, alanine, bicarbonate) with singlet resonant peaks of known chemical shifts. With an in-vivo T1 of ~30s, it provides MR detectable signal only for a very limited time span. The relevant information is spread over five dimensions including chemical-shift (CS), three spatial dimensions and time. In this work, echo time shifted, single-shot spiral encoding is combined with spectrally-preconditioned, minimum-norm CS inversion (minimum-norm IDEAL spiral CSI) to efficiently master this encoding challenge.