Jeff Snyder1, Thomas Lange1, Jrgen Hennig1, Maxim Zaitsev1
1Dept. of Diagnostic Radiology, Medical
A method to detect coupled spins is presented based on PRESS difference spectroscopy with variable refocusing flip angles at 3 T. The technique is optimized by numerical simulations of sixteen metabolite signals at multiple echo times and flip angles, with the end result of reduction of overlap with adjacent signals for the target metabolite while maintaining adequate yield. The procedure is demonstrated for gamma-aminobutyric acid and taurine.