Xi Chen1,2, Shaolin Yang1, Laura Rowland2, Yihong Yang1
1Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States; 2Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, United States
A modified 2D multiple-quantum coherence sequence is proposed to achieve high-resolution selective GABA detection under inhomogeneous fields. The edited spectra of GABA with and without J splittings can be obtained from the sequence. Sparse sampling in the indirect dimension is utilized to reduce the entire acquisition time. A phantom experiment was performed to demonstrate the feasibility of the proposed method and its potential applications for in vivo studies.