Ernesto Akio Yoshimoto Ninamango1, Chenguang
Zhao2, Kaung-Ti Yung2, Weili Zheng2, Elena
Ackley2, Stephen Dager3, John vanMeter4,
Ulrike Dydak5,6, Keith Heberlein7, Shang-Yueh Tsai8,
Fa-Hsuan Lin9,10, Lawrence Wald11, Andre Van Der Kouwe11,
Juan Bustilo12, Stefan Posse1,3
1Electrical Engineering, University of
New Mexico, Albuquerque, NM, United States; 2Department of
Neurology, University of New Mexico, Albuquerque, NM, United States; 3Department
of Radiology, University of Washington, Seattle, WA, United States; 4Department
of Neurology, Georgetown University, Washington, DC, United States; 5Department
of Radiology and Imaging Sciences, Indiana University School of Medicine,
Indianapolis, IN, United States; 6School of Health Sciences,
Purdue University, West Lafayette, IN, United States; 7Siemens
Medical Solutions, Siemens, Erlangen, Germany; 8Department of
Electrical Engineering, Chang Gung University, Tau Yuan, Taiwan; 9Institute
of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 10A.
A. Martinos Center, Massachusetts General Hospital, MA, United States; 11MGH-HMS-MIT
Athinoula A. Martinos Center for Biomedical Imaging; 12Department
of Psychiatry, University of New Mexico, Albuquerque, NM, United States; 13Electrical
and Computer Engineering Department, University of New Mexico
This
multicenter MRSI study presents the results of 3D metabolite mapping in the
brain of healthy subjects at high-spatial resolution (voxels as small as 0.14
cc) and measurement times of less than 11 min. Data were acquired with
short-TE PEPSI on 3T scanners equipped with large-scale head array coils (8
to 32 channels). The resolution of this method provides consistent spectral
quality with narrow spectral width throughout the VOI and enables delineation
of anatomical brain structures in metabolite maps. The short measurement
times (as short as 7 min for 64x64x8 spatial matrix) makes this method
attractive for clinical research studies.