Anu Malik1, Uma Sharma1, R Lakshmy2, Rajiv Narang3, Naranamangalam R. Jagannathan1
1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, Delhi, India; 3Department of Cardiology, All India Institute of Medical Sciences, New Delhi, Delhi, India
We explored the possibility of biomarkers using NMR spectroscopy to differentiate among different forms of coronary artery disease (CAD) like single vessel (SVD), double vessel (DVD) and triple vessel disease (TVD). Elevated levels of LDL/VLDL, Isoleucine/Leucine /Valine, Alanine and alpha-1 glycoprotein were observed in CAD patients (n=112) compared to controls (n=30). Levels of Alanine were significantly different between the three forms of CAD indicating that the chronic bouts of myocardial ischemia may induce alterations in myocardial amino acid metabolism and measurement of myocardial exchange of Glutamate; Alanine and Lactate can be suggested as a sensitive biochemical test.