Jose
Manuel Morales1, Carmen Ivorra2, Javier Chaves3,
Consuelo Garcia-Vicent2, Maria Isabel Torro2, Jose
Redon4, Empar Lurbe2, Daniel Monleon3
1Universitat
de Valencia, Valencia, Spain; 2Hospital General Universitario de
Valencia, Valencia, Spain; 3Fundacion Investigacion Hospital
Clinico Valencia, Valencia, Spain; 4Hospital Clinico Universitario
de Valencia, Valencia, Spain
Blood
pressure is significantly lower in those children with low birth at weight as
compared to those in the other groups. In this communication we present a
study of blood plasma NMR spectra for detecting the metabolic differences
between low and normal weighted newborns. NMR spectra were obtained for
plasma from 51 newborns, of which 20 exhibit weight at birth below 2800 g.
Metabolic profiling of newborn blood plasma reveals statistically significant
differences between low and normal weighted subjects including phenylalanine,
citrulline, glutamine, glycerol and glucose. Interestingly, some of these
metabolites are present in breast milk.