Sonia Gandhi1, Memita Devi1, Shubhra Chaturvedi2, Subash Khushu1
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Division and Cyclotron & Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Cold stress is responsible for affecting multiple biochemical regulatory systems & triggering cardiovascular & respiratory disorders, cognitive impairment, anxiety. Present study investigates the changes in metabolic profiles of urine in rats due to acute cold stress using NMR & multivariate statistical analysis (PCA). Results indicate up regulation of TCA cycle decreasing pyruvate, citrate, 2-oxoglutrate, succinate & fumarate concentration. Creatinine & Hippurate levels were reduced altering gut microbiota. Decreased aromatic amino acids & TMAO also supports kidney dysfunction. Noninvasive monitoring of various biochemical pathways can be done & these results can be used to develop strategies to sustain cold stress.