Sonia Gandhi1, Poonam Rana1, Memita Devi1, Sunil Pal2, Subash Khushu1
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Division and Cyclotron & Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Heat stress exposure can affect physiological & cognitive performance in humans, alter neurotransmitters & hormone level, causes hypohydration affecting cognitive performance. Present study reveals the changes in metabolite pattern & identifies potential biomarkers in rat urine due to heat stress exposure by NMR & multivariate statistical analysis. Phenylalanine, creatinine, hippurate, pyruvate & citrate concentration was reduced indicating onset of thermoregulatory response, altered renal function & enhanced energy consumption. Increased formate indicates disturbed gut flora. These studies reveal the subtle interplay of functional metabolites & pathways leading to an understanding of the systemic response to external stimuli such as heat stress.