Iosif Alexandru Mendichovszky1, Habib Ashoor2, David L. Buckley3, Alan Jackson1
1Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, United Kingdom; 2Physics Department, University of Bahrain, Bahrain; 3University of Leeds, Leeds, United Kingdom
The aims of the study were (1) to investigate the validity of perfusion measurements for normal and pathological tissues using the upslope method (USM) in dynamic CT and MR from computer simulations in non-leaky and leaky capillaries and (2) to explore the effects of SNR and injection rate on the accuracy of perfusion estimates. The USM can be used to calculate perfusion in normal and pathological tissues and is most accurate in tissues with relatively long transit times. Its accuracy can be improved with the use of a rapid injection (sharp AIF) and is decreased by image noise.