Heisoog Kim1,2, Ciprian Catana1,
Grace Kim1, Ovidiu C. Andronesi1, Dominique L. Jennings1,
Divya S. Bolar1,3, Elizabeth R. Gerstner4, Tracy T.
Batchelor4, Rakesh K. Jain5, A Gregory Sorensen1
1A.A.Martinos center, Massachusetts
General Hospotal, Charlestown, MA, United States; 2NSE/HST, Massachusetts
Institute of Technology, Cambridge, MA, United States; 3EECS/HST,
Massachusetts Institute of Technology, Cambridge, MA, United States; 4Neurology,
Massachusetts General Hospotal, Boston, MA, United States; 5Radiology,
Massachusetts General Hospotal, Boston, MA, United States
In
this study, simultaneous BOLD-ASL method was used to assess quantitatively
the characteristic cerebral responses to 100% oxygen exposure in normal brain
and in glioblastoma (GB). BOLD and Flow effects in normal brain were detected
primarily in the cortex (increased BOLD and decreased CBF responses), which
agreed with previously published data. Heterogeneous BOLD signal was observed
in GB. The enhancing tumor showed a larger increase in BOLD and a smaller
decrease responses in CBF than contralateral normal tissue did, which implies
the characteristic properties of the tumor vasculature (i.e. tortuous, large
vessels, inefficient blood circulation).