Jingyi Xie1, Peter Jezzard1,
Linqing Li1, Yazhuo Kong1, Christian F. Beckmann1,2,
Karla L. Miller1, Stephen M. Smith1
1Oxford Centre for Functional MRI of the
Brain, Oxford, United Kingdom; 2Department of Clinical
Neuroscience, Imperial College, London, United Kingdom
There
is increasing interest in resting brain activity. However, to our knowledge,
ASL has not yet been used to study RSNs across the whole brain with single
timeseries acquisitions. In this study, we implemented a novel true
whole-brain CASL technique with EPI readout to study dynamic characteristics
of cerebral blood flow during the resting state. We extracted the major
covarying networks in the resting brain, as imaged in 8 subjects at rest. The
major brain networks are highly similar to recent published results obtained
using BOLD fMRI. We also characterised very low-frequency RSN temporal
behaviour for the first time.