Oliver Hinds1, Aaron Hess2, M. Dylan Tisdall3, Hans Breiter3, Andr van der Kouwe3
1A. A. Martinos Imaging Center at the McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, United States; 2Human Biology, University of Cape Town, Cape Town, South Africa; 3A. A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA, United States
We performed a direct comparison between BOLD signal measured using single-voxel functional spectroscopy (FS) and EPI. A pulse sequence that performed both acquisition methods at each TR was developed and implemented. The FS portion of the sequence was modeled after a PRESS sequence without water suppression. An FS VOI and an EPI slice were positioned to sample the same brain region under visual stimulation. We found that FS gave statistically significantly higher BOLD estimates than EPI, although by a modest amount.