Manus Joseph Donahue1,2, Bradley J. Macintosh2,3, Ediri Sideso4, James Kennedy4, Peter Jezzard1,2
1Clinical Neurology, Oxford University, Oxford, United Kingdom; 2Physics Division, FMRIB Centre, Oxford, United Kingdom; 3Imaging & Brain Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 4Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom
Inflow vascular-space-occupancy with dynamic subtraction (iVASO-DS) has been proposed as a non-invasive approach for measuring arterial cerebral blood volume (aCBV). Here, we compare iVASO-DS contrast with DSC-measured CBF, CBV and MTT in patients with stenotic artery disease. We find consistency between iVASO and DSC-CBV, especially when MTT discrepancies are accounted for. Finally, in patients with moderate-to-severe stenoses, CBF is generally symmetric between unaffected and affected hemispheres (R=0.85), yet iVASO contrast is more asymmetric (R=0.69). This finding is consistent with autoregulatory vasodilation and indicates that aCBV adjustments may precede CBF reductions in patients with stenotic artery disease.