Heisoog Kim1,2, Alexander E. Drzezga1, Ciprian Catana1, Grace Kim1, Ovidiu C. Andronesi1, Dominique L. Jennings1, Elizabeth R. Gerstner3, Tracy T. Batchelor3, Rakesh K. Jain4, Alma Gregory Sorensen1
1A.A.Martinos center, Massachusetts
This pilot study investigated quantitative changes in the default mode network (DMN) in patients with glioblastoma (GB) to understand how brain tumors and their associated treatment affect the integrity of the DMN. In general, it was possible to identify coherent BOLD DMN-activity in brain tumor patients in a similar pattern as demonstrated previously in healthy subjects. However, distinct asymmetry of the DMN was observed with a decreased connectivity of the inferior parietal cortex in tumor-affected hemisphere. The z-score values were reduced in a hemisphere diseased with GB compared to those in a contralateral hemisphere.